Pfam: FKBP_C

Protein families database of alignments and HMMs

  FKBP_C  


Figure 1: 1fkh
Cis-trans isomerase

Key:
DomainChainStart ResidueEnd Residue
FKBP_C 10 104

The Swissprot/PDB mapping was provided by MSD

Accession number: PF00254
Previous identifiers: FKBP;
FKBP-type peptidyl-prolyl cis-trans isomerase
This family forms structural complexes with other Pfam families, to view them click here

INTERPRO description (entry IPR001179)

Synonym(s): Peptidylprolyl cis-trans isomerase

FKBP-type peptidylprolyl isomerases (EC:5.2.1.8) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms.
QuickGO
PROCESS :protein folding (GO:0006457)
For additional annotation, see the PROSITE document PDOC00426 [Expasy|SRS-UK|SRS-USA]

Alignment Domain organisation
Seed (190)  Full (759)

Format

Further alignment options here
Help relating to Pfam alignments here
Seed (190)  Full (759)

As a Graphic As a Tree
Zoom pixels/aa.
Bootstrap tree

To find out about the NIFAS tree-viewer, click here
Species DistributionPhylogenetic tree
View alignments & domain organisation by species
Tree depth :
Seed (190)  Full (759)

The trees were generated using Quicktree
To find out more about ATV phylogenetic tree-viewer click here

Database References
PDB
You can find out how to set up Rasmol here

PROSITE PDOC00426 [Expasy|SRS-UK|SRS-USA]
COGS
COG0545 COG1047
HOMSTRAD
fkbp
PFAMB
PB002280 PB012304 PB105584 PB107107
SYSTERSFKBP_C
PANDITFKBP_C

Pfam specific information
Author of entryFinn RD
Type definitionDomain
Alignment method of seedClustalw
Source of seed membersProsite
Average Length90.7
Average %id30
Average Coverage37.21%

HMMER build information
 Pfam_ls  [Download HMM]Pfam_fs  [Download HMM]
Gathering cutoff -10.2 -10.2; 14.4 14.4
Trusted cutoff-10.1 -10.1; 15.1 15.1
Noise cutoff-10.7 -10.7; 13.8 13.8
Build method of HMMhmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

For help on making stable links to this page click here
 
 Comments or questions on the site? Send a mail to pfam@sanger.ac.uk