Protein families database of alignments and HMMs   FKBP_C

Figure 1: 1fkh Cis-trans isomerase Key: Domain Chain Start Residue End Residue FKBP_C 10 104 The Swissprot/PDB mapping was provided by MSD 1a7x1b6c1bkf1bl41c9h1d6o1d7h1d7i1d7j1eym1f401fap1fd91fkb1fkd1fkf1fkg1fki1fkj1fkk1fkl1fkr1fks1fkt1hxv1ix51j4h1j4i1j4r1jvw1kt01kt11n1a1nsg1qpf1qpl1rot1rou1tco1yat2fap2fke3fap4fap

Accession number: PF00254 Previous identifiers: FKBP; FKBP-type peptidyl-prolyl cis-trans isomerase This family forms structural complexes with other Pfam families, to view them click here INTERPRO description (entry IPR001179) Synonym(s): Peptidylprolyl cis-trans isomerase FKBP-type peptidylprolyl isomerases (EC:5.2.1.8) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms. QuickGO PROCESS : protein folding (GO:0006457)

For additional annotation, see the PROSITE document PDOC00426 [Expasy|SRS-UK|SRS-USA]

Alignment	Domain organisation
Seed (190)  Full (759) Format Coloured alignment Plain Pfam format Plain Stockholm format Fasta format (with gaps) MSF format Belvu (unix only) Belvu (old version unix only) Jalview (Java) Further alignment options here Help relating to Pfam alignments here	Seed (190)  Full (759) As a Graphic As a Tree Zoom pixels/aa. Bootstrap tree To find out about the NIFAS tree-viewer, click here
Species Distribution	Phylogenetic tree
View alignments & domain organisation by species Tree depth : Show all levels 1 level 2 levels 3 levels 4 levels 5 levels	Seed (190)  Full (759) The trees were generated using Quicktree To find out more about ATV phylogenetic tree-viewer click here

Database References
PDB You can find out how to set up Rasmol here	1a7x A; 10; 104; 1a7x B; 10; 104; 1b6c A; 10; 104; 1b6c C; 10; 104; 1b6c E; 10; 104; 1b6c G; 10; 104; 1bkf ; 10; 104; 1bl4 A; 10; 104; 1bl4 B; 10; 104; 1c9h A; 10; 104; 1d6o A; 10; 104; 1d6o B; 10; 104; 1d7h A; 10; 104; 1d7h B; 10; 104; 1d7i A; 10; 104; 1d7i B; 10; 104; 1d7j A; 10; 104; 1d7j B; 10; 104; 1eym A; 10; 104; 1eym B; 10; 104; 1f40 A; 10; 104; 1fap A; 10; 104; 1fd9 A; 116; 207; 1fkb ; 10; 104; 1fkd ; 10; 104; 1fkf ; 10; 104; 1fkg ; 10; 104; 1fkh ; 10; 104; 1fki A; 10; 104; 1fki B; 10; 104; 1fkj ; 10; 104; 1fkk ; 10; 104; 1fkl ; 10; 104; 1fkr ; 10; 104; 1fks ; 10; 104; 1fkt ; 10; 104; 1hxv A; 29; 110; 1ix5 A; 7; 88; 1j4h A; 10; 104; 1j4i A; 10; 104; 1j4r A; 10; 104; 1j4r B; 10; 104; 1j4r D; 10; 104; 1jvw A; 76; 168; 1kt0 A; 156; 248; 1kt0 A; 46; 135; 1kt1 A; 156; 248; 1kt1 A; 42; 135; 1n1a A; 41; 135; 1n1a B; 41; 135; 1nsg A; 10; 104; 1qpf A; 10; 104; 1qpf D; 210; 304; 1qpl A; 10; 104; 1qpl C; 210; 304; 1rot ; 40; 134; 1rou ; 40; 134; 1tco C; 10; 104; 1yat ; 10; 104; 2fap A; 10; 104; 2fke ; 10; 104; 3fap A; 10; 104; 4fap A; 10; 104;
PROSITE	PDOC00426 [Expasy|SRS-UK|SRS-USA]
COGS	COG0545 COG1047
HOMSTRAD	fkbp
PFAMB	PB002280 PB012304 PB105584 PB107107
SYSTERS	FKBP_C
PANDIT	FKBP_C

Pfam specific information Author of entry Finn RD Type definition Domain Alignment method of seed Clustalw Source of seed members Prosite Average Length 90.7 Average %id 30 Average Coverage 37.21% HMMER build information   Pfam_ls  [Download HMM] Pfam_fs  [Download HMM] Gathering cutoff -10.2 -10.2; 14.4 14.4 Trusted cutoff -10.1 -10.1; 15.1 15.1 Noise cutoff -10.7 -10.7; 13.8 13.8 Build method of HMM hmmbuild -F HMM_ls SEED hmmcalibrate --seed 0 HMM_ls hmmbuild -f -F HMM_fs SEED hmmcalibrate --seed 0 HMM_fs

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